People

The lab

Computer scientists, mathematicians, and biologists working together on AI for biology and medicine, alongside collaborators across Yale, academia, and industry.

Co-authorship, 2025–26 papers · grey: collaborators · hover a node
David van Dijk
Principal Investigator

David van Dijk

Associate Professor of Computer Science & Medicine

David van Dijk is Associate Professor of Computer Science and Medicine at Yale, and a member of the Wu Tsai Institute and the Yale Institute for Foundations of Data Science. The lab builds AI systems that learn the rules of biology directly from data, from methods that became standard tools in single-cell genomics (MAGIC, PHATE, MELD, CINEMA-OT) to foundation models that treat biology as a language (Cell2Sentence, C2S-Scale, BrainLM). C2S-Scale, built with Google Research and Google DeepMind, generated a new cancer-immunotherapy hypothesis that was then confirmed in living cells. David trained in computer science at the University of Amsterdam (PhD) and did postdoctoral work at the Weizmann Institute and Columbia University. The lab is supported by an NIH Maximizing Investigators’ Research Award (MIRA, R35) and an NSF CAREER Award.

  • NIH Maximizing Investigators’ Research Award (MIRA, R35)
  • NSF CAREER Award (2025)
  • Google Cloud Research Award (2025)
  • Best Paper, ICML GRL+ Workshop (2020)

Lab members10

Daniel Levine

Daniel Levine

Postdoctoral Associate · Yale–Boehringer Ingelheim Biomedical Data Science Fellow

Daniel joined as a postdoc in 2023 and led the original Cell2Sentence paper, which first taught large language models to read and write single cells. Daniel came to machine learning from pure mathematics (PhD, Penn State, on moduli spaces of vector bundles) and now works on AI systems that reason about genetics and on biologically inspired learning rules for continual learning.

Language models of biologyAgents for geneticsLearning rules
Syed Asad Rizvi

Syed Asad Rizvi

PhD Student · Computer Science

Google PhD Fellowship (2025)

Syed is lead author of C2S-Scale, the 27-billion-parameter model of single-cell biology built with Google. The work extends language models from single cells to tissues and patients: prompt-conditioned cell embeddings, multi-cell tokenization, reinforcement learning for perturbation prediction, and a language for DNA methylation. Syed holds a BS from the University of Houston.

C2S-ScaleVirtual cellsMulti-cell modeling
Sizhuang He

Sizhuang He

PhD Student · Computer Science

Sizhuang develops generative models for data with unusual structure: flow matching with causal language models (CaLMFlow), diffusion over permutations (ICML 2026), and edit-based post-training for biological sequences. Sizhuang also builds multi-agent systems that harmonize public epigenetic data for aging research. Sizhuang studied mathematics at the University of Michigan.

Generative modelingDiffusion on structured spacesAgents for aging research
Shiyang (Harry) Zhang

Shiyang (Harry) Zhang

PhD Student · Computer Science

Harry studies where reasoning in language models comes from. The paper "Intelligence at the Edge of Chaos" (ICLR 2025) showed that models trained on data of the right complexity become better reasoners. Harry now works on multi-agent systems (MoRSE, NeurIPS 2026) and on models that reason about chemistry mechanistically. Harry holds an MS from Columbia and a BSc in Statistics from the University of British Columbia.

Emergent reasoningMulti-agent systemsChemical reasoning
Aakash Patel

Aakash Patel

PhD Student · Computer Science

Salovey–Moret Data Science Fellow (2026)

Aakash builds foundation models and agents for neuroscience and genomics. Aakash is the student lead of the Wu Tsai Institute Foundation Models Grand Challenge and first author of The AI Neuroscientist, an agent that runs neuroimaging analyses through conversation. Aakash was named to the inaugural cohort of Yale’s Salovey–Moret Data Science Fellows. Aakash holds dual master’s degrees in CS and Mathematics from the University of Michigan.

Neuro foundation modelsAI neuroscientistSpatial transcriptomics
Yangtian Zhang

Yangtian Zhang

PhD Student · Computer Science

Yangtian, co-advised with Rex Ying, works on the foundations of generative modeling for sequences. Yangtian led CaDDi (NeurIPS 2025), which unifies causal language models with discrete diffusion, and a variational approach to insertion-based generation with collaborators at Google DeepMind and UCL (ICML 2026).

Discrete diffusionSequence generationMultimodal models
Peiwen Li

Peiwen Li

PhD Student · Computer Science

Peiwen joined in 2025, co-advised with Rex Ying, and designs multi-agent LLM systems that divide scientific and reasoning tasks among specialized roles. Peiwen is first author of MoRSE (NeurIPS 2026), a mixture of role-and-subtask experts for task-oriented agent teams, with broader interests in graph machine learning and causal discovery.

LLM agentsMulti-agent systemsGraph learning
DQ

Daanish Qureshi

PhD Rotation Student · Computational Biology & Biomedical Informatics

Daanish is a first-year CBB PhD student rotating in the lab in fall 2026, working on multi-agent brain simulation and on when feedback-driven iteration beats stored knowledge.

Multi-agent brain simulationFew-shot optimal intelligence
Ivan Vrkic

Ivan Vrkic

Postgraduate Researcher

Ivan works on scaling Cell2Sentence models and on language models for scientific inverse design, including SciDesignBench. Ivan studied at EPFL and TU Wien and previously built control software at CERN.

Scaling Cell2SentenceScientific inverse design
WW

William Wang

Undergraduate Researcher · Yale College

William works with Syed Rizvi on extensions of Cell2Sentence and on the lab’s few-shot optimality project.

Extending Cell2Sentence

Collaborators45

We work with faculty across Yale and beyond. The people below are co-authors and active research partners.

Yale

  • Smita Krishnaswamy Professor of Genetics and Computer Science AI Neuroscientist, TrajectoryNet
  • Rex Ying Assistant Professor of Computer Science MoRSE, CaDDi, FIMP
  • Lu Lu Assistant Professor of Statistics & Data Science TANTE, GeoFunFlow
  • Shreya Saxena Assistant Professor of Biomedical Engineering AI Neuroscientist
  • Jeffrey Ishizuka Associate Professor of Medicine (Oncology) C2S-Scale validation, CINEMA-OT
  • David Braun Associate Professor of Medicine (Oncology) C2S-Scale
  • Brian Hafler Associate Professor of Ophthalmology C2S-Scale
  • Jennifer Kwan Assistant Professor of Medicine C2S-Scale
  • Hattie Chung Assistant Professor of Medicine and MCDB C2S-Scale
  • Albert Higgins-Chen Assistant Professor of Psychiatry Methylation language models, CpG Atlas
  • Stefania Nicoli Professor of Medicine and Genetics
  • Craig Crews John C. Malone Professor of MCDB
  • Victor Batista John Gamble Kirkwood Professor of Chemistry Chemical reasoning models
  • Jessica Cardin Gordon M. Shepherd Professor of Neuroscience Neural Integral Equations, BrainLM
  • Michael Higley Professor of Neuroscience Neural Integral Equations
  • Akiko Iwasaki Sterling Professor of Immunobiology Long COVID
  • David Hafler Edgerly Professor of Neurology Single-cell immunology
  • David Pitt Associate Professor of Neurology
  • Noah Palm Professor of Immunobiology Host–microbe immunity
  • Carrie Lucas Associate Professor of Immunobiology MIS-C
  • Craig Wilen Associate Professor of Laboratory Medicine SARS-CoV-2 CRISPR screens
  • Ellen Foxman Associate Professor of Laboratory Medicine CINEMA-OT
  • Ya-Chi Ho Associate Professor of Microbial Pathogenesis HIV persistence
  • Janghoo Lim Professor of Genetics and Neuroscience SCA1 neurodegeneration
  • Hongyu Zhao Ira V. Hiscock Professor of Biostatistics
  • R. Andrew Taylor Director of AI & Data Science, Emergency Medicine HEART, COVID severity

Beyond Yale

  • Chadi Abdallah Associate Professor of Psychiatry, Baylor College of Medicine BrainLM
  • Emanuele Zappala Assistant Professor of Mathematics, Idaho State University Neural Integral Equations, Edge of Chaos
  • Raghav Sehgal Faculty, Harvard Medical School · formerly Yale PhD and Associate Research Scientist (Higgins-Chen lab) Aging clocks, methylation language models
  • Arthur Gretton Professor, Gatsby Unit, UCL Insertion-based generation
  • Guy Wolf Professor, Université de Montréal & Mila TrajectoryNet
  • Aaron Ring Associate Professor, Fred Hutchinson Cancer Center Long COVID
  • David Putrino Professor, Icahn School of Medicine at Mount Sinai Long COVID
  • Christine Chaffer Associate Professor, Garvan Institute AAnet

Industry

  • Amin Karbasi VP & Chief AI Scientist, Cisco Foundation AI · Adjunct Professor, Stanford Intelligence at the Edge of Chaos, FIMP
  • Bryan Perozzi Google Research C2S-Scale
  • Shekoofeh Azizi Google DeepMind C2S-Scale
  • Michalis Titsias Google DeepMind Insertion-based generation
  • Paul Jaeger Latent Labs C2S-Scale
  • Jiaxin Shi Meta Superintelligence Labs Insertion-based generation

Student & visiting collaborators

  • Haote LiPhD, Yale Chemistry (Batista lab) · now MerckChemSeek
  • Daiheng ZhangPhD student, Rutgers ECESTRIDE
  • Sifan WangPostdoc, Yale FDS (Lu group)TANTE, GeoFunFlow
  • Rahul DhodapkarOphthalmology resident, USCCell2Sentence, C2S-Scale, CINEMA-OT
  • Tetiana ParshakovaPhD, Stanford · now Flatiron InstituteVisiting researcher, 2024

Alumni43

Postdoctoral researchers

  • Neal Ravindra2019–2021 Postdoctoral Associate · the lab’s first postdoc→ Xaira Therapeutics
  • Arijit Sehanobish2019–2021 Postdoctoral Associate
  • Emanuele Zappala2019–2023 Postdoctoral Associate · Neural Integral Equations→ Assistant Professor of Mathematics, Idaho State University
  • Nazreen Pallikkavaliyaveetil2022–2024 Postdoctoral Associate→ Eli Lilly
  • Josue Ortega Caro2022–2025 Wu Tsai Postdoctoral Fellow, with Jess Cardin · BrainLM
  • Maryam Bagherian2022–2023 Postdoctoral Associate→ Assistant Professor of Mathematics, Idaho State University
  • Sina Ghadermarzi2023–2024 Postdoctoral Associate, with Akiko Iwasaki
  • Cerise Tang2024–2025 Postdoctoral Associate, with David Braun

Graduate students

  • Antonio Henrique de Oliveira Fonseca2019–2023 PhD, Interdepartmental Neuroscience Program
  • Mingze Dong2020–2023 Graduate Researcher, CBB · CINEMA-OT→ Postdoctoral Fellow, Stanford & Arc Institute
  • Sacha Lévy2023–2024 Graduate Researcher, Computer Science→ Founder, Y Combinator-backed startup
  • Marlene Li2024–2025 Master’s Student
  • Peng Chen2026 Master’s Student, Computer Science

Research staff & postgraduates

  • Xingyu Chen2023–2024 Postgraduate Associate→ PhD student, University of Toronto
  • Zihe Zheng2023 Research Assistant
  • Marco Bressana2023–2024 Research Intern
  • Emily Sun2024–2025 Research Intern→ Bioinformatician, Mount Sinai
  • Shawn Wahi2024–2026 Postgraduate Researcher
  • Olin Geimer2024–2025 Postgraduate Fellow · behavioral foundation models

Medical students

  • Matteo Rosati2023–2025 Medical Student Researcher · BrainLM→ MD, Yale School of Medicine (2026)
  • James Cross2023–2024 Undergraduate, then Researcher · BrainLM→ MD student, Yale School of Medicine

Visiting & summer researchers

  • Zhuoyang (Robinson) Lyu2024–2025 Visiting Researcher (Brown)→ MMSc Biomedical Informatics, Harvard Medical School
  • Zhikai (Zaki) Wu2024–2025 Visiting Student (Peking University) · TANTE→ PhD student, NYU Courant
  • Eva Cao2024 Summer Researcher (Cambridge) · CaLMFlow
  • Jans Solano2025 Remote Researcher · BrainLM v2

Undergraduate researchers

  • David Zhang2021–2026 Statistics & CS
  • Lawrence Zhao2023–2025 CS · CaDDi, C2S-Scale→ PhD student in CS, UIUC (NSF GRFP)
  • Neil Sachdeva2023–2024 Senior thesis
  • Daphne Raskin2023–2024 Cell2Sentence
  • David Jeong2024–2026 CS & Statistics · C2S-Scale
  • Sophia Dai2024–2025 BrainLM
  • Sartaj Rajpal2024–2025 Senior thesis
  • Teo Dimov2024–2025 Discrete diffusion
  • Luis Chan2024–2025 Cell2Sentence
  • Ian Wang2025 Senior thesis
  • Mati Hassan2025 Senior project
  • Eric Li2025–2026 Senior project
  • Meghana Chamarty2025–2026 Senior thesis
  • Richard Lin2025–2026 Senior project · multi-omic C2S
  • Aanika Tiwary2025–2026 Cardiac foundation model · C2S-TCGA
  • Ruiyan Huang2025–2026 Senior project · methylation LLMs
  • Sameer Bhatti2026 Data engineering for C2S
  • Yavin Fickel2026 STARS summer researcher

Earlier students, rotators & interns (2019–2023) Yavuz Nuzumlali · Jeremy Gygi · Biqing Zhu · Rishabh Gupta · Shivam Saboo · Noah Lee · Zade Akras · Saejong Park · Longtian Ye · Prastik Mohanraj